Mark Fletcher in many ways embodies the successful Web startup entreprenuer, having created and sold two multi-million dollar companies - ONEList to Yahoo (via a merger with eGroups) and Bloglines to Ask Jeeves. Niall Kennedy has notes, audio and a transcript of a talk Fletcher recently did. This is pretty much required reading for budding 2.0 entrepreneurs. Here's a sample:

"Garage Philosophy
- Solve a Pain Point
- Have Passion for the Idea
- Be Cheap!!
- Release Early/Release Often (3 Month Rule) - Doesn't Have to be Perfect
- Involve Your Users"

I wonder what Fletcher will build next, he seems to have a nose for what will be the Next Big Thing on the Web...