Korean company Egoing has introduced MonkeyFly, a browser plugin that allows a user to customize their Twitter. For users who feel the abiding need for monkeying around (rimshot) with everything they use, this could come in handy.
Among the features the plugin powers are a grid-style interface, lightbox profile, link tracking and easy photo upload.
Currently MonkeyFly supports Firefox and Google Chrome. If you're a Safari user, speak Korean. Otherwise you're out of luck. 
The focus is both on providing a customizable experience but also setting all the functions of the application to hand, such as incoming Tweets and @ references.
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Korean company