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Twitter has gone mainstream. Late last night, Ashton Kutcher (@aplusk) became the first Twitter user with more than 1 million followers. Today, media mogul Oprah Winfrey sent out her first tweet and will dedicate a full episode of her talk show to Twitter.

While Twitter's sudden mainstream appeal might be somewhat disconcerting for early adopters who would prefer it if Twitter wasn't suddenly the cool new thing to try out for soccer moms, it will surely bring a lot of new opportunities (and challenges) for Twitter.

While Ashton Kutcher and CNN are trying to be the first to hit 1 million followers on Twitter, Joseph Frieschel, an inconspicuous Australian MD, is quickly catching up. Frieschel only opened his Twitter account last night, but he already has over 200,000 followers. How can this be? Well, it looks like the anonymous members of the infamous 4chan imageboard didn't like the idea of either Kutcher or CNN breaking the 1 million follower barrier before they got a chance to make their presence felt.